6-Nitroveratraldehyde
- Product Name
- 6-Nitroveratraldehyde
- CAS No.
- 20357-25-9
- Chemical Name
- 6-Nitroveratraldehyde
- Synonyms
- DMNB;NVAD;NVAD20357-25-9;ASISCHEM R27925;DNA-K Inhibitor;6-nitroveratrol;DNA-PK Inhibitor;TIMTEC-BB SBB000505;6-NITROVERATRALDEHYDE;6-Nitroveratrumaldehyd
- CBNumber
- CB4275729
- Molecular Formula
- C9H9NO5
- Formula Weight
- 211.17
- MOL File
- 20357-25-9.mol
6-Nitroveratraldehyde Property
- Melting point:
- 131-133 °C (lit.)
- Boiling point:
- 350.84°C (rough estimate)
- Density
- 1.4194 (rough estimate)
- refractive index
- 1.5700 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO: 22 mg/mL
- form
- solid
- color
- yellow
- Water Solubility
- Insoluble in water. Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO.
- Sensitive
- Air & Light Sensitive
- BRN
- 395599
- CAS DataBase Reference
- 20357-25-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 6-Nitroveratraldehyde(20357-25-9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 279609
- Product name
- 6-Nitroveratraldehyde
- Purity
- technical grade, 80%
- Packaging
- 5g
- Price
- $50.2
- Updated
- 2024/03/01
- Product number
- 260960
- Product name
- DNA-PK Inhibitor
- Packaging
- 10mg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- N0538
- Product name
- 6-Nitroveratraldehyde
- Purity
- >85.0%(GC)
- Packaging
- 5g
- Price
- $112
- Updated
- 2024/03/01
- Product number
- N0538
- Product name
- 6-Nitroveratraldehyde
- Purity
- >85.0%(GC)
- Packaging
- 25g
- Price
- $447
- Updated
- 2024/03/01
- Product number
- A14415
- Product name
- 6-Nitroveratraldehyde, 96%
- Packaging
- 5g
- Price
- $57.3
- Updated
- 2024/03/01
6-Nitroveratraldehyde Chemical Properties,Usage,Production
Chemical Properties
yellow fluffy powder
Uses
6-Nitroveratraldehyde has been used in the preparation of no-carrier-added 6-18F-fluoro-L-dopa, fundamental tracer for cerebral positron emission tomography studies of dopaminergic system in humans and o-nitroaryl-bis(5-methylfur-2-yl)methanes, versatile synthons for the synthesis of nitrogen-containing heterocycles. DMNB is also an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair. It is also used for synthesizing analogs of alpha-asarone.
Definition
ChEBI: 4,5-dimethoxy-2-nitrobenzaldehyde is a C-nitro compound and an aromatic ether.
General Description
A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) activity (IC50 = 15 μM) and DNA-PK-mediated double strand break (DSB) DNA repair by non-homologous DNA-end-joining (NHEJ). Reported to effectively sensitize cells to Cisplatin (Cat. No. 232120). Does not affect the activities of PKC or Chk2.
Biological Activity
Inhibitor of DNA-dependent protein kinase (DNA-PK) (IC 50 = 15 μ M), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Displays 100-fold higher potency than its analog vanillin and does not affect PKC activity. Produces lethal effects on cisplatin-treated D5037 cells upon continuous exposure.
Biochem/physiol Actions
Cell permeable: yes
Purification Methods
The aldehyde is purified by dissolving 9g in 200mL of boiling 95% EtOH, and set aside overnight to crystallise. It is then dried in vacuo at 50o and recrystallised from 110mL of 95% EtOH to give 6-7g of aldehyde with m 132-133o. Crystallisation from aqueous EtOH provides light yellow needles. It is light sensitive and should be stored in the dark [Fetscher Org Synth Coll Vol 4 735 1963]. [Beilstein 8 H 262, 8 I 610, 8 II 290, 6 III 2065, 6 IV 1785.]
6-Nitroveratraldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Nitroveratraldehyde manufacturers
- Product
- 6-Nitroveratraldehyde 20357-25-9
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25
- Product
- 6-Nitroveratraldehyde 20357-25-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-07-27
- Product
- 6-Nitroveratraldehyde 20357-25-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2023-02-10